2476559-00-7
Chemical Structure
Topoisomerase II inhibitor 11
- CAS No.: 2476559-00-7
- Formula:C27H21BrCl2N2O2S
- Molecular Weight:588.34
IUPAC Name: ethyl 3,5-bis(4-chlorophenyl)-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate hydrobromide
InChIKey: IXCMDLNDDZUXJY-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br
Biological Activity: Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
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Topoisomerase II inhibitor 11 | Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity. | |||||||||||||||||||||
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Keywords
