2494001-21-5

PARP1-IN-10 Chemical Structure
2494001-21-5

Chemical Structure

PARP1-IN-10

  • CAS No.: 2494001-21-5
  • Formula:C20H23N3O5
  • Molecular Weight:385.41

IUPAC Name: 1,3-dimethyl-5-(4-(2-oxo-2-(piperidin-1-yl)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

InChIKey: VKLCODKLVUQTBY-UHFFFAOYSA-N

SMILES: O=C1/C(C(N(C)C(N1C)=O)=O)=C\C2=CC=C(C=C2)OCC(N3CCCCC3)=O

Biological Activity: PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) [1].

Cat. No. Product Name Purity Description Pricing
HY-149003 		PARP1-IN-10 PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) .
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