2519450-32-7
2519450-32-7
Chemical Structure
PDE4-IN-9
- CAS No.: 2519450-32-7
- Formula:C15H12N4O3S
- Molecular Weight:328.35
IUPAC Name: (Z)-N-(3-(2-(4-methoxyphenyl)oxazole-4-carbonyl)thiazolidin-2-ylidene)cyanamide
InChIKey: BNSGBZBUZFHIRM-ICFOKQHNSA-N
SMILES: COC1=CC=C(C=C1)C2=NC(C(N3CCS/C3=N\C#N)=O)=CO2
Biological Activity: PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].
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PDE4-IN-9 | PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS. | |||||||||||||||||||||
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References
Keywords
