265989-47-7
265989-47-7
Chemical Structure
Ortho-hydroxy atorvastatin-d5 calcium
- CAS No.: 265989-47-7
- Formula:C33H30D5FN2O6.1/2Ca
- Molecular Weight:599.71
IUPAC Name: 3-(carboxy-d)-2,2,5,5-tetrakis(methyl-d3)pyrrolidin-1-olate-3,4,4-d3-1-15N
SMILES: OC1=C(NC(C2=C(N(C(C3=CC=C(F)C=C3)=C2C4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])CC[C@H](C[C@H](CC(O)=O)O)O)C(C)C)=O)C=CC=C1.[Ca].[1/2]
Biological Activity: Ortho-hydroxy atorvastatin-d5 calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577)[1]. Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589)[2].
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Ortho-hydroxy atorvastatin-d5 calcium | Ortho-hydroxy atorvastatin-d5 calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577). Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589). | |||||||||||||||||||||
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2-Hydroxy atorvastatin calcium salt | 98.01% | 2-Hydroxy atorvastatin calcium salt is an orally active OATP1B1 substrate and inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase). 2-Hydroxy atorvastatin calcium salt enters cells via OATP1B1-mediated cellular uptake and inhibits de novo hepatic cholesterol synthesis. As an active metabolite of Atorvastatin (HY-B0589), 2-Hydroxy atorvastatin calcium salt contributes to the inhibitory activity against plasma HMG-CoA reductase. 2-Hydroxy atorvastatin calcium salt can be biotransformed into an inactive lactone form, which can be hydrolyzed back to its active acid form chemically or enzymatically. 2-Hydroxy atorvastatin (calcium salt) can be used in the research of hypercholesterolemia. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Zhou Y, et al. Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous determination of amlodipine, atorvastatin and its metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin in human plasma and its application in a bioequivalence study. J Pharm Biomed Anal. 2013 Sep;83:101-7. [Content Brief]
