2671004-41-2
Chemical Structure
PROTAC MEK1 Degrader-1
- CAS No.: 2671004-41-2
- Formula:C53H66FIN8O11S2
- Molecular Weight:1201.17
InChIKey: RQBUNBWHIATPNI-WQWWALRQSA-N
SMILES: O=S(NC(C=C(C(N1C)=O)C)=C1NC2=C(C=C(C=C2)I)F)(C3=CC=C(C=C3)CCC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)=O
Biological Activity: PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].
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PROTAC MEK1 Degrader-1 | 98.03% | PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells. | ||||||||||||||||||||
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Keywords
