2714434-21-4
2714434-21-4
Chemical Structure
IAG933
Synonym(s): YAP-TEAD-IN-3
- CAS No.: 2714434-21-4
- Formula:C27H26ClF2N3O4
- Molecular Weight:529.96
InChIKey: HUVOYQMXUNTUAI-DCFHFQCYSA-N
SMILES: ClC(C(F)=CC1=C2C[C@](C3=CC=CC=C3)([C@@H]4CCCN4)O1)=[C@]2[C@@]5=C(C(NC)=O)C=NC(OCCO)=C5F
Biological Activity: IAG933 (YAP-TEAD-IN-3) is an orally available YAP/TAZ-TEAD inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD4217-434, with an IC50 value of 9 nM[1][2].
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IAG933 | 99.47% | IAG933 (YAP-TEAD-IN-3) is an orally available YAP/TAZ-TEAD inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD4217-434, with an IC50 value of 9 nM. | ||||||||||||||||||||
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References
- [1]. Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.
- [2]. Emilie A Chapeau， et al. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer. 2024 Jul;5(7):1102-1120. [Content Brief]
Keywords
