273388-09-3
273388-09-3
Chemical Structure
WAY-150138
- CAS No.: 273388-09-3
- Formula:C22H18Cl2FN3O3S
- Molecular Weight:494.37
IUPAC Name: N-(3-chloro-4-(3-(5-chloro-2,4-dimethoxyphenyl)thioureido)phenyl)-2-fluorobenzamide
InChIKey: NPZHFWHOVNAVCF-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1F)NC2=CC=C(C(Cl)=C2)NC(NC3=CC(Cl)=C(C=C3OC)OC)=S
Biological Activity: WAY-150138 inhibits replication of herpes simplex virus type 1 (HSV-1) that acts by preventing the incorporation of DNA-packaging proteins into capsids as they are assembled[1][2]
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WAY-150138 | WAY-150138 inhibits replication of herpes simplex virus type 1 (HSV-1) that acts by preventing the incorporation of DNA-packaging proteins into capsids as they are assembled | |||||||||||||||||||||
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References
- [1]. William W. Newcomb, et al. Inhibition of Herpes Simplex Virus Replication by WAY-150138: Assembly of Capsids Depleted of the Portal and Terminase Proteins Involved in DNA Encapsidation. 2002 Oct; 76(19): 10084–10088. [Content Brief]
- [2]. M van Zeijl, et al. Novel class of thiourea compounds that inhibit herpes simplex virus type 1 DNA cleavage and encapsidation: resistance maps to the UL6 gene. J Virol. 2000 Oct;74(19):9054-61. [Content Brief]
Keywords
