2755843-62-8
Chemical Structure
RET-IN-14
- CAS No.: 2755843-62-8
- Formula:C24H23FN8O4
- Molecular Weight:506.49
IUPAC Name: methyl (4-((S,13E,14E)-17-amino-45-fluoro-6-methyl-9-oxo-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(3,2)-pyridinacyclononaphane-16-yl)phenyl)carbamate
InChIKey: URGGTFUKULFJKT-LBPRGKRZSA-N
SMILES: NC1=C(C2=CC=C(C=C2)NC(OC)=O)C3=NC4=C(C(NC[C@@H](OC5=NC=C(F)C=C5CN3)C)=O)C=NN14
Biological Activity: RET-IN-14 (compound 49) is a potent RET inhibitor with IC50s of <0.51 nM, 9.3 nM, 1.3 nM, 9.2 nM, 15 nM for RET (WT), RET (G810R), RET (V804M), BTK and BTK (C481S), respectively. RET-IN-14 has the potential for tumors research[1]
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RET-IN-14 | RET-IN-14 (compound 49) is a potent RET inhibitor with IC50s of <0.51 nM, 9.3 nM, 1.3 nM, 9.2 nM, 15 nM for RET (WT), RET (G810R), RET (V804M), BTK and BTK (C481S), respectively. RET-IN-14 has the potential for tumors research | |||||||||||||||||||||
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Keywords
