2761858-59-5
Chemical Structure
CDK1-IN-1
- CAS No.: 2761858-59-5
- Formula:C27H23N5O3
- Molecular Weight:465.50
IUPAC Name: 2-((2,4-dimethoxyphenyl)amino)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
InChIKey: YQSMYKNXCIPBBV-UHFFFAOYSA-N
SMILES: O=C(C1=C2N=C(C3=CC=CC=C3)C=C(C4=CC=CC=C4)N2N=C1NC5=CC=C(OC)C=C5OC)N
Biological Activity: CDK1-IN-1 is a potent CDK1 inhibitor (CDK1/CycB IC50=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent[1].
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CDK1-IN-1 | 99.33% | CDK1-IN-1 is a potent CDK1 inhibitor (CDK1/CycB IC50=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent. | ||||||||||||||||||||
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- [1]. Elgiushy HR, et al. Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105646. [Content Brief]
Keywords
