2765453-51-6
2765453-51-6
Chemical Structure
TTBK1-IN-2
- CAS No.: 2765453-51-6
- Formula:C18H13ClN4O
- Molecular Weight:336.78
IUPAC Name: N-(4-(4-chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
InChIKey: RWRSKMSFZCQDMQ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(OC2=CC=C(C=C2)NC3=C4C(NC=C4)=NC=N3)C=C1
Biological Activity: TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 µM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TTBK1-IN-2 | 99.91% | TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 µM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice. | ||||||||||||||||||||
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References
Keywords
