TTBK1
Tau tubulin kinase 1 (TTBK1) belongs to the CK1 group of the kinome and phosphorylates both tau protein and β-tubulin at proline-directed Ser/Thr motifs. It is enriched in brain, where TTBK1 has been proposed to contribute to tau hyperphosphorylation in Alzheimer disease, and it also acts in ciliogenesis and cell-cycle progression. Structurally, TTBK1 combines an N-terminal catalytic domain with a large C-terminal proline-rich tail. Its paralog TTBK2 differs by regulating ciliary trafficking and causing spinocerebellar ataxia. Because recombinant TTBK1 is active on tau substrates, it is widely used for kinase assays and inhibitor profiling in tauopathy research.
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TTBK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
