2767204-39-5
Chemical Structure
PROTAC BTK Degrader-6
- CAS No.: 2767204-39-5
- Formula:C45H47N11O6
- Molecular Weight:837.92
InChIKey: SPGWKNITNYHIGX-UHFFFAOYSA-N
SMILES: O=C(CN1CCN(CC2CN(C3=CC(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)=C5C=C3)C2)CC1)N(CC6)CCC6N7C8=C(C(N)=NC=N8)C(C(C=C9)=CC=C9OC%10=CC=CC=C%10)=N7
Biological Activity: PROTAC BTK Degrader-6 is an orally active PROTAC-based BTK degrader with a DC50 of 3.18 nM. PROTAC BTK Degrader-6 induces BTK degradation via proteasomal degradation, ubiquitination, and CRBN ligase recruitment pathways. PROTAC BTK Degrader-6 inhibits NF-κB activation, mRNA expression of IL-1β and IL-6, as well as the secretion of pro-inflammatory cytokines. PROTAC BTK Degrader-6 reduces inflammatory responses in a zymosan-induced mouse model of peritonitis. PROTAC BTK Degrader-6 can be used in peritonitis-related research[1].
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PROTAC BTK Degrader-6 | 99.24% | PROTAC BTK Degrader-6 is an orally active PROTAC-based BTK degrader with a DC50 of 3.18 nM. PROTAC BTK Degrader-6 induces BTK degradation via proteasomal degradation, ubiquitination, and CRBN ligase recruitment pathways. PROTAC BTK Degrader-6 inhibits NF-κB activation, mRNA expression of IL-1β and IL-6, as well as the secretion of pro-inflammatory cytokines. PROTAC BTK Degrader-6 reduces inflammatory responses in a zymosan-induced mouse model of peritonitis. PROTAC BTK Degrader-6 can be used in peritonitis-related research. | ||||||||||||||||||||
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Keywords
