2785323-68-2
Chemical Structure
T0080
- CAS No.: 2785323-68-2
- Formula:C24H22F3N3O3
- Molecular Weight:457.44
InChIKey: NLNJUYHGBAJDBQ-UHFFFAOYSA-N
SMILES: OC1=CC=C(C)C=C1C2=C(C(C3=CC=C(C(F)(F)F)C=C3)N(C4CCOCC4)C5=O)C5=NN2
Biological Activity: T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA-associated hemorrhagic transformation, inhibits demyelination responses and the expression of NOX2. T0080 also possesses anti-apoptotic (apoptosis) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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T0080 | 99.94% | T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA-associated hemorrhagic transformation, inhibits demyelination responses and the expression of NOX2. T0080 also possesses anti-apoptotic (apoptosis) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis. | ||||||||||||||||||||
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- [1]. Lv J, et al. Formyl peptide receptor 1 signaling exacerbates hemorrhagic transformation following tPA thrombolysis in mice. J Cereb Blood Flow Metab. 2026;46(3):682-694. [Content Brief]
- [2]. Li Y, et al. Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration. Science. 2025;390(6774):eadq1177. [Content Brief]
Keywords
