2934053-07-1
2934053-07-1
Chemical Structure
Indapamide-13C,d3
- CAS No.: 2934053-07-1
- Formula:C1513CH13D3ClN3O3S
- Molecular Weight:369.85
IUPAC Name: 4-chloro-N-(2-(methyl-13C-d3)indolin-1-yl)-3-sulfamoylbenzamide
InChIKey: NDDAHWYSQHTHNT-KQORAOOSSA-N
SMILES: O=C(C1=CC=C(C(S(=O)(N)=O)=C1)Cl)NN2C3=C(CC2[13C]([2H])([2H])[2H])C=CC=C3
Biological Activity: Indapamide-13C,d3 is 13C and deuterium labeled Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4][5].
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Indapamide-13C,d3 | Indapamide-13C,d3 is 13C and deuterium labeled Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy. | |||||||||||||||||||||
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Indapamide (Standard) | 99.79% | Indapamide (Standard) is the analytical standard of Indapamide. This product is intended for research and analytical applications. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy. | ||||||||||||||||||||
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(rac)-Indapamide-d3 | (rac)-Indapamide-d3 is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy. | |||||||||||||||||||||
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Indapamide | 99.62% | Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [4]. Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16(2):361-70. [Content Brief]
- [5]. Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95. [Content Brief]
