2951015-30-6
2951015-30-6
Chemical Structure
YD54
- CAS No.: 2951015-30-6
- Formula:C40H42FN9O6
- Molecular Weight:763.82
InChIKey: WBWCGTJXNCHFJI-UHFFFAOYSA-N
SMILES: O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3OCCN4CCN(C5=C(F)C=C(CN6CCN(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)CC6)C=C5)CC4
Biological Activity: YD54 is an orally active and selective SMARCA2 PROTAC degrader. YD54 induces SMARCA4 degradation but with low potency and selectivity. YD54 selectively inhibits the growth of various cancer cells and suppresses tumor growth in mouse xenograft models. YD54 can be used for the research of SMARCA4-mutant lung cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YD54 | 98.74% | YD54 is an orally active and selective SMARCA2 PROTAC degrader. YD54 induces SMARCA4 degradation but with low potency and selectivity. YD54 selectively inhibits the growth of various cancer cells and suppresses tumor growth in mouse xenograft models. YD54 can be used for the research of SMARCA4-mutant lung cancer. | ||||||||||||||||||||
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References
- [1]. Kotagiri S, et al. Discovery of Novel, Potent, and Orally Bioavailable SMARCA2 Proteolysis-Targeting Chimeras with Synergistic Antitumor Activity in Combination with Kirsten Rat Sarcoma Viral Oncogene Homologue G12C Inhibitors. Journal of medicinal chemistry. 2025 May 08;68(9):9202-9219. [Content Brief]
Keywords
