2988849-20-1
Chemical Structure
LJ-4517
- CAS No.: 2988849-20-1
- Formula:C19H21N5O3S
- Molecular Weight:399.47
IUPAC Name: (2R,3R,4R)-2-(6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
InChIKey: MUHXGASCCALSAJ-PRIMNGNOSA-N
SMILES: O[C@H]1[C@H](N2C(C3=CC=CS3)=NC4=C(N)N=C(C#CCCCC)N=C24)OC[C@H]1O
Biological Activity: LJ-4517 is a potent A2AAR antagonist, with a Ki of 18.3 nM. LJ-4517 is potent in displacing the binding of [3H]ZM241385 (HY-19532) at WT A2AAR[1]. LJ-4517 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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LJ-4517 | LJ-4517 is a potent A2AAR antagonist, with a Ki of 18.3 nM. LJ-4517 is potent in displacing the binding of [3H]ZM241385 (HY-19532) at WT A2AAR. LJ-4517 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Keywords
