3006860-57-4
Chemical Structure
Si5-N14
- CAS No.: 3006860-57-4
- Formula:C78H160N6O5Si2
- Molecular Weight:1318.31
InChIKey: QJDZHMBJSTXKDI-UHFFFAOYSA-N
SMILES: O=C(CCN(CCC[Si](C)(C)O[Si](C)(CCCN(CCC(NCCCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCCCC)=O)C)CCC(NCCCCCCCCCCCCCC)=O)NCCCCCCCCCCCCCC
Biological Activity: Si5-N14 is a key component of siloxane-incorporated lipid nanoparticles (SiLNP), possessing pro-vascular repair and anti-tumor activities. In the transgenic GFP mouse model, Si5-N14 can mediate CRISPR-Cas9 editing. In the Lewis lung carcinoma (LLC) tumor-bearing mouse model, Si5-N14 can knock out the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) to exert an anti-tumor effect. In a mouse model of lung injury induced by viral infection, the delivery of Fibroblast Growth Factor-2 (FGF-2) mRNA via Si5-N14 can promote vascular repair, increase blood oxygen levels, and improve lung function. Si5-N14 shows promise for research in the fields of oncology, pneumonia, and cardiovascular diseases[1].
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Si5-N14 | Si5-N14 is a key component of siloxane-incorporated lipid nanoparticles (SiLNP), possessing pro-vascular repair and anti-tumor activities. In the transgenic GFP mouse model, Si5-N14 can mediate CRISPR-Cas9 editing. In the Lewis lung carcinoma (LLC) tumor-bearing mouse model, Si5-N14 can knock out the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) to exert an anti-tumor effect. In a mouse model of lung injury induced by viral infection, the delivery of Fibroblast Growth Factor-2 (FGF-2) mRNA via Si5-N14 can promote vascular repair, increase blood oxygen levels, and improve lung function. Si5-N14 shows promise for research in the fields of oncology, pneumonia, and cardiovascular diseases. | |||||||||||||||||||||
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Keywords
