3009849-06-0
Chemical Structure
BJG-05-039
- CAS No.: 3009849-06-0
- Formula:C41H44ClF3N8O5
- Molecular Weight:821.29
IUPAC Name: (3-bromo-1-methyl-1H-pyrazol-4-yl)methanol
InChIKey: UZPKWEBZEBROEX-AYTRYJACSA-N
SMILES: FC(F)CN1C2=C(C=C(Cl)C=C2)C(N[C@H]3CCN(C(NCCCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)=O)C3)=NC7=CC(F)=CC=C17
Biological Activity: BJG-05-039 is a PAK1-selective degrader consisting of NVS-PAK1-1 (HY-100519) conjugated to Lenalidomide (HY-A0003). BJG-05-039 induces selective degradation of PAK1. BJG-05-039 inhibits phosphorylation of MEK S298, as well as inhibiting phosphorylation of ERK. BJG-05-039 has an anti-proliferative effect on PAK1-dependent cell lines[1].
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BJG-05-039 | 98.06% | BJG-05-039 is a PAK1-selective degrader consisting of NVS-PAK1-1 (HY-100519) conjugated to Lenalidomide (HY-A0003). BJG-05-039 induces selective degradation of PAK1. BJG-05-039 inhibits phosphorylation of MEK S298, as well as inhibiting phosphorylation of ERK. BJG-05-039 has an anti-proliferative effect on PAK1-dependent cell lines. | ||||||||||||||||||||
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Keywords
