3029138-70-0
3029138-70-0
Chemical Structure
JAK/HDAC-IN-3
- CAS No.: 3029138-70-0
- Formula:C28H37FN6O5S
- Molecular Weight:588.69
IUPAC Name: 7-(4-((4-((3-(N-(tert-butyl)sulfamoyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-fluorophenoxy)-N-hydroxyheptanamide
InChIKey: XQYXAGOVMRYFIS-UHFFFAOYSA-N
SMILES: CC(NS(C1=CC(NC2=NC(NC3=CC=C(C(F)=C3)OCCCCCCC(NO)=O)=NC=C2C)=CC=C1)(=O)=O)(C)C
Biological Activity: JAK/HDAC-IN-3 (13a) is a dual JAK and HDAC inhibitor, with IC50 values of 25.36 nM, 0.2 μM and 0.43 μM for JAK2, HDAC and HDAC1, respectively[1].
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JAK/HDAC-IN-3 | JAK/HDAC-IN-3 (13a) is a dual JAK and HDAC inhibitor, with IC50 values of 25.36 nM, 0.2 μM and 0.43 μM for JAK2, HDAC and HDAC1, respectively. | |||||||||||||||||||||
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References
Keywords
