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Cat. No.: HY-149284

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JAK/HDAC-IN-3

JAK/HDAC-IN-3 (13a) is a dual JAK and HDAC inhibitor, with IC₅₀ values of 25.36 nM, 0.2 μM and 0.43 μM for JAK2, HDAC and HDAC1, respectively.

For research use only. We do not sell to patients.

CAS No.: 3029138-70-0
Formula: C₂₈H₃₇FN₆O₅S
Molecular Weight:588.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

JAK/HDAC-IN-3 Chemical Structure

CAS No.: 3029138-70-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

JAK/HDAC-IN-3 (13a) is a dual JAK and HDAC inhibitor, with IC₅₀ values of 25.36 nM, 0.2 μM and 0.43 μM for JAK2, HDAC and HDAC1, respectively^[1].

All JAK Isoforms :

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.27 μM Compound: 30	Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]
HEL	IC₅₀	0.24 μM Compound: 30	Antiproliferative activity against HEL cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against HEL cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]
HeLa	IC₅₀	3.25 μM Compound: 30	Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]
HL-60	IC₅₀	3.37 μM Compound: 30	Antiproliferative activity against human HL-60 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HL-60 cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]
K562	IC₅₀	1.22 μM Compound: 30	Antiproliferative activity against human K562 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human K562 cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]
MCF7	IC₅₀	1.98 μM Compound: 30	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]
PC-3	IC₅₀	3.04 μM Compound: 30	Antiproliferative activity against human PC-3 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human PC-3 cells incubated for 72 hrs by CCK-8 assay	[PMID: 37057760]

Chemical Information

CAS No. 3029138-70-0
Molecular Weight 588.69
Formula C₂₈H₃₇FN₆O₅S
SMILES

CC(NS(C1=CC(NC2=NC(NC3=CC=C(C(F)=C3)OCCCCCCC(NO)=O)=NC=C2C)=CC=C1)(=O)=O)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qianqian Qiu, et al. Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers. J Med Chem. 2023 Apr 27;66(8):5753-5773. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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JAK/HDAC-IN-3

All JAK Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JAK/HDAC-IN-3 Related Classifications

HY-149284 Related Classifications