3032264-62-0
Chemical Structure
AChE-IN-22
- CAS No.: 3032264-62-0
- Formula:C21H20N4O5S
- Molecular Weight:440.47
IUPAC Name: N-methyl-N-(3-(4-nitrophenoxy)propyl)-2-(2-oxo-2-(thiophen-2-yl)ethyl)pyrimidine-5-carboxamide
InChIKey: FJTAEXLOOHICDN-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CS1)CC2=NC=C(C=N2)C(N(CCCOC3=CC=C(C=C3)[N+]([O-])=O)C)=O
Biological Activity: AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC50 values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease[1].
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AChE-IN-22 | AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC50 values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
