3051829-20-7
3051829-20-7
Chemical Structure
PI3Kδ-IN-24
- CAS No.: 3051829-20-7
- Formula:C28H29N7O4
- Molecular Weight:527.57
SMILES: COC1=C(C=C(C2=CC=C3N=CN=C(C3=N2)N[C@@H](C)C(N4CCN(CC4)C)=O)C=N1)C(OC5=CC=CC=C5)=O
Biological Activity: PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM). PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL)[1].
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PI3Kδ-IN-24 | PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM). PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL). | |||||||||||||||||||||
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References
Keywords
