3053592-61-0
3053592-61-0
Chemical Structure
PARP1-IN-47
- CAS No.: 3053592-61-0
- Formula:C21H24F3N7O2
- Molecular Weight:463.46
InChIKey: ZDIHDVXIIAYFFT-UHFFFAOYSA-N
SMILES: O=C(N1)C(CC)=CN2C1=CC(CN3CCN(CC3)C4=C(C(F)(F)F)N=C(C(NC)=O)C=C4)=N2
Biological Activity: PARP1-IN-47 (Compound 35) is a highly selective PARP1 inhibitor (IC50 <100 nM). PARP1-IN-47 blocks poly(ADP-ribosyl)ation and disrupts DNA damage repair pathways to induce tumor cell apoptosis. PARP1-IN-47 is promising for research of solid tumors and hematological malignancies[1].
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PARP1-IN-47 | PARP1-IN-47 (Compound 35) is a highly selective PARP1 inhibitor (IC50 <100 nM). PARP1-IN-47 blocks poly(ADP-ribosyl)ation and disrupts DNA damage repair pathways to induce tumor cell apoptosis. PARP1-IN-47 is promising for research of solid tumors and hematological malignancies. | |||||||||||||||||||||
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References
Keywords
