3069195-42-9
3069195-42-9
Chemical Structure
ZWZH-21
- CAS No.: 3069195-42-9
- Formula:C26H22N4O2
- Molecular Weight:422.48
SMILES: O=C(NC1=C(N)C=CC=C1)C2=CC=C(OCCN3C(C=NC=C4)=C4C5=C3C=CC=C5)C=C2
Biological Activity: ZWZH-21 is a selective and orally active HDAC1/2 dual inhibitor with IC50 values of 34 nM for HDAC1 and 41 nM for HDAC2. ZWZH-21 can inhibit HCT116 and SW480 cells growth with IC50 values of 0.524 μM and 1.063 μM, respectively. ZWZH-21 can inhibit proliferation and migration and induces apoptosis in multiple colorectal cancer cells. ZWZH-21 can be used for the research of cancer, such as colorectal cancer[1].
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ZWZH-21 | ZWZH-21 is a selective and orally active HDAC1/2 dual inhibitor with IC50 values of 34 nM for HDAC1 and 41 nM for HDAC2. ZWZH-21 can inhibit HCT116 and SW480 cells growth with IC50 values of 0.524 μM and 1.063 μM, respectively. ZWZH-21 can inhibit proliferation and migration and induces apoptosis in multiple colorectal cancer cells. ZWZH-21 can be used for the research of cancer, such as colorectal cancer. | |||||||||||||||||||||
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References
Keywords
