3113890-51-7
Chemical Structure
PROTAC IRAK4 degrader-14
- CAS No.: 3113890-51-7
- Formula:C59H68FN5O13
- Molecular Weight:1074.20
InChIKey: VRBJKAVUNPKJFS-MEOQOARSSA-N
SMILES: O=C(O[C@H]([C@H]1CC[C@]23[H])[C@]2(C(C1=C)=O)[C@]4(O)OC[C@@]53[C@@H](O)CCC([C@@]5([H])[C@@H]4O)(C)C)CCC(N6CCC7(CCN(CC7)C(C8=CC=C(C#CC9=CN=C(OC[C@H]([C@@H]%10CC)NC([C@H]%10F)=O)C%11=CC(OC)=C(C(N)=O)C=C9%11)C=C8)=O)C6)=O
Biological Activity: PROTAC IRAK4 degrader-14 is an orally active IRAK4 PROTAC degrader with a DC50 of 2.4 nM. PROTAC IRAK4 degrader-14 inhibits proinflammatory responses in multiple cell types including T cells, monocytes and keratinocytes. PROTAC IRAK4 degrader-14 is applicable to research related to psoriasis[1].
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PROTAC IRAK4 degrader-14 | PROTAC IRAK4 degrader-14 is an orally active IRAK4 PROTAC degrader with a DC50 of 2.4 nM. PROTAC IRAK4 degrader-14 inhibits proinflammatory responses in multiple cell types including T cells, monocytes and keratinocytes. PROTAC IRAK4 degrader-14 is applicable to research related to psoriasis. | |||||||||||||||||||||
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Keywords
