3121876-09-0
Chemical Structure
S27-1047
- CAS 番号: 3121876-09-0
- Formula:C25H16F2N8O3
- Molecular Weight:514.44
InChIKey: TUMFZGYFMWKUFG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C2=NOC(C3=CC=C(F)C=C3F)=N2)=C1)CN4C(C5=NON=C5N)=NC6=CC=CC=C46
Biological Activity: S27-1047 is a brain-penetrant, potent and selective BChE (eqBChE IC50 = 7.16 nM; hBChE IC50 = 296.10 nM) inhibitor and Nrf2 activator. S27-1047 can directly bind Keap1, disrupt Keap1-Nrf2 interaction (FP IC50 = 36.87 nM), enhance antioxidant enzyme expression and activate the GSH-GPX4 axis to inhibit Aβ-induced ferroptosis. S27-1047 can protect against oxidative stress and neuroinflammation. S27-1047 can be used in Alzheimer's disease research[1].
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S27-1047 | S27-1047 is a brain-penetrant, potent and selective BChE (eqBChE IC50 = 7.16 nM; hBChE IC50 = 296.10 nM) inhibitor and Nrf2 activator. S27-1047 can directly bind Keap1, disrupt Keap1-Nrf2 interaction (FP IC50 = 36.87 nM), enhance antioxidant enzyme expression and activate the GSH-GPX4 axis to inhibit Aβ-induced ferroptosis. S27-1047 can protect against oxidative stress and neuroinflammation. S27-1047 can be used in Alzheimer's disease research. | |||||||||||||||||||||
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Keywords
