376645-66-8
Chemical Structure
N-Acetyl-D-mannosamine-d3-1
- CAS No.: 376645-66-8
- Formula:C8H12D3NO6
- Molecular Weight:224.23
InChIKey: OVRNDRQMDRJTHS-UQQFJJNZSA-N
SMILES: OC[C@H]1OC([C@H]([C@H]([C@@H]1O)O)NC(C([2H])([2H])[2H])=O)O
Biological Activity: N-Acetyl-D-mannosamine-d3-1 is the deuterated-labeled N-Acetyl-D-mannosamine (HY-128850). N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders[1][2][3][4][5].
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N-Acetyl-D-mannosamine-d3-1 | N-Acetyl-D-mannosamine-d3-1 is the deuterated-labeled N-Acetyl-D-mannosamine (HY-128850). N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders. | |||||||||||||||||||||
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References
- [1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101. [Content Brief]
- [2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778. [Content Brief]
- [3]. Peng J, et al. Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. 2019 Dec 10;140(24):2005-2018. [Content Brief]
- [4]. Niethamer TK, et al. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Mol Genet Metab. 2012 Dec;107(4):748-55. [Content Brief]
- [5]. Taniguchi S, et al. Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse. Neurosci Lett. 2015 Jun 26;598:41-6. [Content Brief]
