38241-28-0
Chemical Structure
Zinterol hydrochloride
Synonym(s): MJ 9184 hydrochloride
- CAS No.: 38241-28-0
- Formula:C19H27ClN2O4S
- Molecular Weight:414.95
IUPAC Name: N-(2-hydroxy-5-(1-hydroxy-2-((2-methyl-1-phenylpropan-2-yl)amino)ethyl)phenyl)methanesulfonamide hydrochloride
InChIKey: LVNUBJDWJFOMKH-UHFFFAOYSA-N
SMILES: CS(=O)(NC1=CC(C(CNC(C)(CC2=CC=CC=C2)C)O)=CC=C1O)=O.[H]Cl
Biological Activity: Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3].
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Zinterol hydrochloride | 99.72% | Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits. | ||||||||||||||||||||
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- [1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [Content Brief]
- [2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [Content Brief]
- [3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. [Content Brief]
Keywords
