1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Zinterol hydrochloride

Zinterol hydrochloride (Synonyms: MJ 9184 hydrochloride)

Cat. No.: HY-14304A Purity: >99.0%
Handling Instructions

Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.

For research use only. We do not sell to patients.

Zinterol hydrochloride Chemical Structure

Zinterol hydrochloride Chemical Structure

CAS No. : 38241-28-0

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10 mM * 1  mL USD 424 In-stock
Estimated Time of Arrival: December 31
1 mg USD 155 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Zinterol hydrochloride:

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Description

Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2].

IC50 & Target

β2-adrenoceptor[1]

In Vivo

Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3].

Animal Model: In New Zealand White HF rabbits of either sex[3]
Dosage: 1.0 or 2.5 μg/kg
Administration: Intravenous bolus administration; over 5 seconds
Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
Molecular Weight

414.95

Formula

C₁₉H₂₇ClN₂O₄S

CAS No.

38241-28-0

SMILES

CS(=O)(NC1=CC(C(CNC(C)(CC2=CC=CC=C2)C)O)=CC=C1O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

ZinterolMJ 9184MJ9184MJ-9184Adrenergic ReceptorBeta Receptorβ2-adrenoceptorVentriculartachycardiaheartfailureInhibitorinhibitorinhibit

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Product Name:
Zinterol hydrochloride
Cat. No.:
HY-14304A
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