2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Zinterol hydrochloride

Zinterol hydrochloride  (Synonyms: MJ 9184 hydrochloride)

Cat. No.: HY-14304A Purity: 99.34%
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Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits.

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Zinterol hydrochloride Chemical Structure

Zinterol hydrochloride Chemical Structure

CAS No. : 38241-28-0

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 424 In-stock
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5 mg USD 465 In-stock
10 mg USD 795 In-stock
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Based on 1 publication(s) in Google Scholar

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Zinterol hydrochloride Related Antibodies

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Description

Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3].

IC50 & Target

β2-adrenoceptor[1]
In Vivo

Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: In New Zealand White HF rabbits of either sex[3]
Dosage: 1.0 or 2.5 μg/kg
Administration: Intravenous bolus administration; over 5 seconds
Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
Molecular Weight

414.95

Formula

C19H27ClN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=CC(C(CNC(C)(CC2=CC=CC=C2)C)O)=CC=C1O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4099 mL 12.0496 mL 24.0993 mL
5 mM 0.4820 mL 2.4099 mL 4.8199 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.51%

COA (248 KB) LCMS (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4099 mL 12.0496 mL 24.0993 mL 60.2482 mL
5 mM 0.4820 mL 2.4099 mL 4.8199 mL 12.0496 mL
10 mM 0.2410 mL 1.2050 mL 2.4099 mL 6.0248 mL
15 mM 0.1607 mL 0.8033 mL 1.6066 mL 4.0165 mL
20 mM 0.1205 mL 0.6025 mL 1.2050 mL 3.0124 mL
25 mM 0.0964 mL 0.4820 mL 0.9640 mL 2.4099 mL
30 mM 0.0803 mL 0.4017 mL 0.8033 mL 2.0083 mL
40 mM 0.0602 mL 0.3012 mL 0.6025 mL 1.5062 mL
50 mM 0.0482 mL 0.2410 mL 0.4820 mL 1.2050 mL
60 mM 0.0402 mL 0.2008 mL 0.4017 mL 1.0041 mL
80 mM 0.0301 mL 0.1506 mL 0.3012 mL 0.7531 mL
100 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6025 mL
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Zinterol hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinterol38241-28-0MJ 9184MJ9184MJ-9184Adrenergic ReceptorBeta Receptorβ2-adrenoceptorVentriculartachycardiaheartfailureInhibitorinhibitorinhibit

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