449733-84-0
Chemical Structure
Specneuzhenide
Synonym(s): Nuezhenide
- CAS No.: 449733-84-0
- Formula:C31H42O17
- Molecular Weight:686.65
IUPAC Name: methyl (2S,4S,Z)-3-ethylidene-4-(2-oxo-2-(((2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(4-hydroxyphenethoxy)tetrahydro-2H-pyran-2-yl)methoxy)ethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydro-2H-pyran-5-carboxylate
InChIKey: STKUCSFEBXPTAY-GSUVRYNNSA-N
SMILES: C/C=C1[C@@H](C(C(OC)=O)=CO[C@H]/1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)CC(OC[C@H]3O[C@H]([C@@H]([C@H]([C@@H]3O)O)O)OCCC4=CC=C(C=C4)O)=O
Biological Activity: Specneuzhenide (Nuezhenide) is an orally active phenol glycoside isolated from Ligustrum sinense. Specneuzhenide exhibits anti-inflammatory, antioxidant, antifibrotic, antitumor, hypoglycemic, as well as cartilage- and kidney-protective activities. Specneuzhenide inhibits fibrosis by activating the AMPK pathway (Kd = 62 µM), alleviates inflammation and oxidative stress by regulating multiple signaling pathways (NF-κB, Wnt/β-catenin and HO-1/Nrf-2), and upregulates podocyte proteins to comprehensively protect renal function. Specneuzhenide can be used in research related to cancer, rheumatoid arthritis, pulmonary fibrosis, diabetic nephropathy and osteoarthritis[1][2][3][4].
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Specneuzhenide | Specneuzhenide (Nuezhenide) is an orally active phenol glycoside isolated from Ligustrum sinense. Specneuzhenide exhibits anti-inflammatory, antioxidant, antifibrotic, antitumor, hypoglycemic, as well as cartilage- and kidney-protective activities. Specneuzhenide inhibits fibrosis by activating the AMPK pathway (Kd = 62 µM), alleviates inflammation and oxidative stress by regulating multiple signaling pathways (NF-κB, Wnt/β-catenin and HO-1/Nrf-2), and upregulates podocyte proteins to comprehensively protect renal function. Specneuzhenide can be used in research related to cancer, rheumatoid arthritis, pulmonary fibrosis, diabetic nephropathy and osteoarthritis. | |||||||||||||||||||||
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References
- [1]. Wu Y, et al. Specneuzhenide improves bleomycin-induced pulmonary fibrosis in mice via AMPK-dependent reduction of PD-L1. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun;128:155318. [Content Brief]
- [2]. Zeng Z, et al. Specneuzhenide Ameliorate Complete Freund Adjuvant Induced Arthritis in Rats: Involvement of NF-κB and HO-1/Nrf-2 Pathway. Journal of oleo science. 2022;71(4):551-561.
- [3]. Wang QQ, et al. Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway. Curr Mol Pharmacol. 2021;14(1):101-111.
- [4]. Yin J, et al. Protective Effects of Specneuzhenide on Renal Injury in Rats with Diabetic Nephropathy. Open medicine (Warsaw, Poland). 2019;14:740-747. [Content Brief]
