Protective Effects of Specneuzhenide on Renal Injury in Rats with Diabetic Nephropathy

  • Open Med (Wars). 2019 Oct 6:14:740-747. doi: 10.1515/med-2019-0085.
Jiangning Yin  1 ,  Jun Jiang  2 ,  Huajun Wang  3 ,  Guoyuan Lu  4
Affiliations
  • 1. Department of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China.
  • 2. Traditional Chinese Medicine and Pharmacy Department, School of Pharmacy Jiang Su University, Jiang Su 212013, China.
  • 3. Pharmaceutical Department, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China.
  • 4. Urology Department,No. 188, Shizi Street, Urology Department, The First Affiliated Hospital of Soochow University, Suzhou 213006, China.
PMID: 31637305 DOI: 10.1515/med-2019-0085
Abstract

Background: We aim to investigate the protective effects and potential mechanisms in specneuzhenide (SPE) on renal injury in rats with diabetic nephropathy (DN).

Results: SPE could inhibit the decrease of body weight compared with the model group (P<0.05), and trigger improvement in the renal index (P<0.05). High dose and low dose SPE could trigger a significant decrease in serum IL1β, IL-6 and TNF-α compared with the model group (P<0.05). SPE could attenuate the glomerular lesions in DN rats. SPE induced up-regulation of podocin and CD2AP (P<0.05).

Conclusion: SPE showed protective effects on renal injury through attenuating the pathological injury and urine protein. This process may be closely related to the modulation of CD2AP and podocin expression.

Keywords
Diabetic nephropathy; Inflammation; Podocyte; Renal injury; Slit diaphragm protein; Specnuezhenide.
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