491586-42-6
491586-42-6
Chemical Structure
AN5777
- CAS No.: 491586-42-6
- Formula:C19H17N3O2
- Molecular Weight:319.36
InChIKey: ARBAVLNDKREMOX-RGVLZGJSSA-N
SMILES: CC1=C(N=C(C)C(C(N/N=C/C2=CC=CC=C2O)=O)=C3)C3=CC=C1
Biological Activity: AN5777 is a GSPT1 Molecular glue degrader with a DC50 of less than 10 μM. AN5777 degrades GSPT1 in a CRBN-dependent manner via the ubiquitin-proteasome system. AN5777 induces G1 phase arrest and Apoptosis in cancer cells. AN5777 is applicable to research related to acute myeloid leukemia, multiple myeloma, and chronic myeloid leukemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AN5777 | 98.37% | AN5777 is a GSPT1 Molecular glue degrader with a DC50 of less than 10 μM. AN5777 degrades GSPT1 in a CRBN-dependent manner via the ubiquitin-proteasome system. AN5777 induces G1 phase arrest and Apoptosis in cancer cells. AN5777 is applicable to research related to acute myeloid leukemia, multiple myeloma, and chronic myeloid leukemia. | ||||||||||||||||||||
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References
- [1]. Zhang S, et al. Identification of novel GSPT1 degraders by virtual screening and bioassay. European journal of medicinal chemistry. 2024 Jul 05;273:116524. [Content Brief]
- [2]. Cheng B, et al. Research Progress in Targeting GSPT1: Molecular Glues, Bifunctional Degraders, and Antibody-Enabled Molecular Glues for Cancer Therapy. Journal of medicinal chemistry. 2025 Jul 10;68(13):13169-13185.
