AN5777
Based on 1 Customer Validation
AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity .
For research use only. We do not sell to patients.
- Purity: 98.37%
- CAS No.: 491586-42-6
- Formula: C19H17N3O2
- Molecular Weight:319.36
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
16.74 μM
Compound: AN5777
|
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTS assay
|
[PMID: 38795517] |
| OCI-AML2 | IC50 |
2.64 μM
Compound: AN5777
|
Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs by MTS assay
|
[PMID: 38795517] |
| U-266 | IC50 |
3.8 μM
Compound: AN5777
|
Antiproliferative activity against human U-266 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human U-266 cells incubated for 48 hrs by MTS assay
|
[PMID: 38795517] |
| U-937 | IC50 |
4.49 μM
Compound: AN5777
|
Antiproliferative activity against human U-937 cells incubated for 48 hrs by MTS assay
Antiproliferative activity against human U-937 cells incubated for 48 hrs by MTS assay
|
[PMID: 38795517] |
Chemical Information
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CAS No. 491586-42-6
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Appearance Solid
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Molecular Weight 319.36
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Formula C19H17N3O2
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Color Off-white to gray
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SMILES
CC1=C(N=C(C)C(C(N/N=C/C2=CC=CC=C2O)=O)=C3)C3=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)