844903-52-2
Chemical Structure
GSK-163090 dihydrochloride
- CAS No.: 844903-52-2
- Formula:C25H31Cl2N5O
- Molecular Weight:488.45
IUPAC Name: 1-(3-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethyl)phenyl)imidazolidin-2-one dihydrochloride
InChIKey: NYZRWDMGYQYXEQ-UHFFFAOYSA-N
SMILES: O=C1NCCN1C2=CC=CC(CCN3CCN(C4=C5C=CC(C)=NC5=CC=C4)CC3)=C2.Cl.Cl
Biological Activity: GSK-163090 dihydrochloride is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4, 8.5 and 9.7, respectively. GSK-163090 dihydrochloride inhibits the functional activity of serotonin reuptake transporter (SerT) with a pKi value of 6.1. GSK-163090 dihydrochloride has antidepressant and anxiolytic activities[1].
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GSK-163090 dihydrochloride | GSK-163090 dihydrochloride is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4, 8.5 and 9.7, respectively. GSK-163090 dihydrochloride inhibits the functional activity of serotonin reuptake transporter (SerT) with a pKi value of 6.1. GSK-163090 dihydrochloride has antidepressant and anxiolytic activities. | |||||||||||||||||||||
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Keywords
