87424-25-7
87424-25-7
Chemical Structure
3-Demethylthiocolchicine
- CAS No.: 87424-25-7
- Formula:C21H23NO5S
- Molecular Weight:401.48
IUPAC Name: (S)-N-(3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
InChIKey: PKYOHQGXPPVIGD-HNNXBMFYSA-N
SMILES: COC1=C2C(C([C@H](CCC2=CC(O)=C1OC)NC(C)=O)=C3)=CC=C(SC)C3=O
Biological Activity: 3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity[1][2].
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3-Demethylthiocolchicine | 3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity. | |||||||||||||||||||||
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3-Demethylthiocolchicine-13C2,d6 | 3-Demethyl Thiocolchicine---13C2,d6 is 13C and deuterated labeled 3-Demethyl Thiocolchicine-. | |||||||||||||||||||||
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References
- [1]. Kerkes P, et al. Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl-and 3-demethylthiocolchicine[J]. Journal of medicinal chemistry, 1985, 28(9): 1204-1208. [Content Brief]
- [2]. Wolach B, et al. Colchicine analogues: effect on amyloidogenesis in a murine model and, in vitro, on polymorphonuclear leukocytes[J]. European journal of clinical investigation, 1992, 22(9): 630-634. [Content Brief]
