3-Demethylthiocolchicine
Based on 1 Customer Validation
3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity.
For research use only. We do not sell to patients.
- CAS No.: 87424-25-7
- Formula: C21H23NO5S
- Molecular Weight:401.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Cytoskeleton Compound Library
HY-L060
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Anti-Lung Cancer Compound Library
HY-L075
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
30 nM
Compound: 7
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In vitro cytotoxicity against L1210 (murine leukemia) cells.
In vitro cytotoxicity against L1210 (murine leukemia) cells.
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[PMID: 2299625] |
Chemical Information
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CAS No. 87424-25-7
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Appearance Solid
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Molecular Weight 401.48
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Formula C21H23NO5S
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SMILES
COC1=C2C(C([C@H](CCC2=CC(O)=C1OC)NC(C)=O)=C3)=CC=C(SC)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (311.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kerkes P, et al. Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl-and 3-demethylthiocolchicine[J]. Journal of medicinal chemistry, 1985, 28(9): 1204-1208. [Content Brief]
[2]. Wolach B, et al. Colchicine analogues: effect on amyloidogenesis in a murine model and, in vitro, on polymorphonuclear leukocytes[J]. European journal of clinical investigation, 1992, 22(9): 630-634. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4908 mL | 12.4539 mL | 24.9078 mL | 62.2696 mL |
| 5 mM | 0.4982 mL | 2.4908 mL | 4.9816 mL | 12.4539 mL | |
| 10 mM | 0.2491 mL | 1.2454 mL | 2.4908 mL | 6.2270 mL | |
| 15 mM | 0.1661 mL | 0.8303 mL | 1.6605 mL | 4.1513 mL | |
| 20 mM | 0.1245 mL | 0.6227 mL | 1.2454 mL | 3.1135 mL | |
| 25 mM | 0.0996 mL | 0.4982 mL | 0.9963 mL | 2.4908 mL | |
| 30 mM | 0.0830 mL | 0.4151 mL | 0.8303 mL | 2.0757 mL | |
| 40 mM | 0.0623 mL | 0.3113 mL | 0.6227 mL | 1.5567 mL | |
| 50 mM | 0.0498 mL | 0.2491 mL | 0.4982 mL | 1.2454 mL | |
| 60 mM | 0.0415 mL | 0.2076 mL | 0.4151 mL | 1.0378 mL | |
| 80 mM | 0.0311 mL | 0.1557 mL | 0.3113 mL | 0.7784 mL | |
| 100 mM | 0.0249 mL | 0.1245 mL | 0.2491 mL | 0.6227 mL |
3-Demethylthiocolchicine Related Classifications
HY-W355463 Related Classifications
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