Catechin 7-O-β-D-glucopyranoside
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.67%
- CAS 番号: 65597-47-9
- 分子式: C21H24O11
- 分子量:452.41
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Catechin 7-O-β-D-glucopyranoside (10 μg/mL; 24 h) shows protective effect against Streptozotocin-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RINm5F rat pancreatic β-cells
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Concentration:10 μg/mL
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Incubation Time:24 hours
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Result:Increased the MnSOD level attenuated by Streptozotocin treatment.
Restored the Streptozotocin-induced reduction in mitochondrial CAT level.
Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice injected with LPS/D-GalN[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; 10 mg/kg; once
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Result:Showed 80% LPS/DGalN-induced lethality in mice.
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Animal Model:Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis [2]
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Dosage:10 mg/kg
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Administration:Oral administration; 10 mg/kg; once daily; 7 days
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Result:Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats.
Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats.
化学情報
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CAS 番号 65597-47-9
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性状 Solid
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分子量 452.41
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分子式 C21H24O11
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Color White to off-white
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SMILES
OC1=C2C(O[C@H](C3=CC(O)=C(C=C3)O)[C@H](C2)O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 125 mg/mL (276.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zheng MS, et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica. Arch Pharm Res. 2011 Sep;34(9):1443-50. [Content Brief]
[2]. Kook SH, et al. Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. Int Immunopharmacol. 2015 Dec;29(2):521-527. [Content Brief]
[3]. Kim KC, et al. Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells. Cell Biochem Funct. 2010 Dec 2;28(8):651-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2104 mL | 11.0519 mL | 22.1038 mL | 55.2596 mL |
| 5 mM | 0.4421 mL | 2.2104 mL | 4.4208 mL | 11.0519 mL | |
| 10 mM | 0.2210 mL | 1.1052 mL | 2.2104 mL | 5.5260 mL | |
| 15 mM | 0.1474 mL | 0.7368 mL | 1.4736 mL | 3.6840 mL | |
| 20 mM | 0.1105 mL | 0.5526 mL | 1.1052 mL | 2.7630 mL | |
| 25 mM | 0.0884 mL | 0.4421 mL | 0.8842 mL | 2.2104 mL | |
| 30 mM | 0.0737 mL | 0.3684 mL | 0.7368 mL | 1.8420 mL | |
| 40 mM | 0.0553 mL | 0.2763 mL | 0.5526 mL | 1.3815 mL | |
| 50 mM | 0.0442 mL | 0.2210 mL | 0.4421 mL | 1.1052 mL | |
| 60 mM | 0.0368 mL | 0.1842 mL | 0.3684 mL | 0.9210 mL | |
| 80 mM | 0.0276 mL | 0.1381 mL | 0.2763 mL | 0.6907 mL | |
| 100 mM | 0.0221 mL | 0.1105 mL | 0.2210 mL | 0.5526 mL |
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