Catechin 7-O-β-D-glucopyranoside

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Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research.

For research use only. We do not sell to patients.

Catechin 7-O-β-D-glucopyranoside Chemical Structure

CAS No. : 65597-47-9

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
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Description

In Vitro

Catechin 7-O-β-D-glucopyranoside (10 μg/mL; 24 h) shows protective effect against Streptozotocin-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:	RINm5F rat pancreatic β-cells
Concentration:	10 μg/mL
Incubation Time:	24 hours
Result:	Increased the MnSOD level attenuated by Streptozotocin treatment. Restored the Streptozotocin-induced reduction in mitochondrial CAT level.

In Vivo

Catechin 7-O-β-D-glucopyranoside (intraperitoneal injection; 10 mg/kg; once) treatment shows mild protective effect against lethality induced by LPS/D-GalN^[1].
Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice injected with LPS/D-GalN^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 10 mg/kg; once
Result:	Showed 80% LPS/DGalN-induced lethality in mice.

Animal Model:	Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis ^[2]
Dosage:	10 mg/kg
Administration:	Oral administration; 10 mg/kg; once daily; 7 days
Result:	Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats. Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats.

Molecular Weight

452.41

Formula

C₂₁H₂₄O₁₁

CAS No.

65597-47-9

Appearance

Solid

SMILES

OC1=C2C(O[C@H](C3=CC(O)=C(C=C3)O)[C@H](C2)O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1

Structure Classification

Phenols

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zheng MS, et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica. Arch Pharm Res. 2011 Sep;34(9):1443-50. [Content Brief]

[2]. Kook SH, et al. Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. Int Immunopharmacol. 2015 Dec;29(2):521-527. [Content Brief]

[3]. Kim KC, et al. Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells. Cell Biochem Funct. 2010 Dec 2;28(8):651-60. [Content Brief]

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Catechin 7-O-β-D-glucopyranoside65597-47-9Othersantioxidant activityanti-inflammatory activitymitochondrial dysfunctionRINm5F rat pancreatic β-cellInhibitorinhibitorinhibit

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Catechin 7-O-β-D-glucopyranoside