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Cat. No.: HY-187932

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Ceftiolene

Ceftiolene is a cephalosporin that inhibits Gram-negative bacteria. Ceftiolene binds to PBP. Ceftiolene induces bacterial lysis, autolytic activity, filamentation, and porin regulation. Ceftiolene can be used in research on bacterial infections and Pseudomonas aeruginosa infections.

For research use only. We do not sell to patients.

CAS No.: 77360-52-2
Formula: C₂₀H₁₈N₈O₈S₃
Molecular Weight:594.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ceftiolene Chemical Structure

CAS No.: 77360-52-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Ceftiolene exhibits high affinity for essential PBPs, particularly PBP3 in E. coli W7 and Ent. cloacae 40345, as well as PBP1 and PBP3 in Staph. aureus 209P^[2].
Ceftiolene effectively induces filamentation in E. coli W7, Ent. cloacae 40345, and Pr. mirabilis A223 at low concentrations^[2].
Ceftiolene is highly effective in inducing lysis of Ent. cloacae 4041, K. pneumoniae K2, and E. coli Cla, with activity comparable or superior to other third-generation cephalosporins, although an inoculum effect exists for its activity against E. coli Cla/TEM-2^[2].
Ceftiolene effectively triggers autolytic activity in E. coli W7, resulting in significant release of labeled peptidoglycan^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 77360-52-2
Molecular Weight 594.60
Formula C₂₀H₁₈N₈O₈S₃
SMILES

OC(C1=C(/C=C/SC(N(C2=O)CC=O)=NNC2=O)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC)=O)([H])N1C3=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patel MV, et al. WO 2011/101710 A1. 2011.

[2]. Williamson R, et al. An evaluation of the bacteriolytic and biochemical properties of ceftiolene (42980RP). J Antimicrob Chemother. 1984 Dec;14(6):581-93.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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