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Art. -Nr.: HY-P11865

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Ac-ATS010-KE

Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes.

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CAS. Nr.: 2379342-67-1
Formel: C₄₃H₄₁F₅N₆O₁₂S
Molecular Weight:960.88

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

Ac-ATS010-KE Chemical Structure

CAS. Nr.: 2379342-67-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Caspase-3

Alle Caspase Isoform-spezifische Produkte anzeigen :

In Vitro

Ac-ATS010-KE potently inhibits purified recombinant caspase-3 and exhibits high selectivity over caspase-6, caspase-7, caspase-8, caspase-9, and caspase-10^[1].
Ac-ATS010-KE protects Jurkat cells from MegaFasL-induced apoptosis, with non-methylated Ac-ATS010-KE showing superior performance compared to its per-methylated counterpart^[1].
Ac-ATS010-KE (25 µM; 1 hour) reduces [¹⁸F]MICA-316 uptake in STS-treated caspase-3-positive HeLa cells, demonstrating competitive binding to caspase-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ac-ATS010-KE-derived radiotracer [¹⁸F]MICA-316 (~18.5 MBq; intravenous injection) binds to activated caspase-3 in tumor homogenates in vitro, and exhibits low and non-differential tumor uptake^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2379342-67-1
Molecular Weight 960.88
Formel C₄₃H₄₁F₅N₆O₁₂S
Sequence

Ac-Pal-Asp-{Phe(F5)}-Phe-Asp-KE
Sequence Shortening

Ac-{Pal}-D-{Phe(F5)}-FD-KE
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lauwerys L, et al. Development of caspase-3-selective activity-based probes for PET imaging of apoptosis. EJNMMI Radiopharm Chem. 2024 Aug;9:58.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Ac-ATS010-KE

Alle Caspase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Ac-ATS010-KE Related Classifications

HY-P11865 Related Classifications