HDAC1-IN-10
HDAC1-IN-10 (Compound 2b) is a potent, selective and orally active HDAC1/2 inhibitor with IC50 values of 6 and 190 nM. HDAC1-IN-10 shows IC50 > 50 μM for HDAC3-8. HDAC1-IN-10 can inhibit tumor growth in HCT-116 colon xenograft nude mice model. HDAC1-IN-10 can be used for research of colon cancer.
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- CAS. Nr.: 849233-98-3
- Formel: C25H22N4O3S
- Molecular Weight:458.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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HDAC1 6 nM (IC50) |
HDAC2 190 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
155 nM
Compound: 2b
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Growth inhibition of human HCT116 cells
Growth inhibition of human HCT116 cells
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[PMID: 18060775] |
HDAC1-IN-10 can inhibit HCT-116 cells proliferation with an GI50 of 155 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 849233-98-3
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Molecular Weight 458.53
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Formel C25H22N4O3S
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SMILES
O=C(NCC1=CC=C(C(NC2=C(N)C=CC(C3=CC=CS3)=C2)=O)C=C1)OCC4=CC=CN=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC1-IN-10 Related Classifications
HY-173160 Related Classifications
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