HDAC3-IN-1
Based on 1 publication(s) in Google Scholar
HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.28%
- CAS. Nr.: 2044701-99-5
- Formel: C20H23N3O2
- Molecular Weight:337.42
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HDAC3-IN-1
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Biologische Aktivität
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HDAC3 5.96 ± 0.0 nM (IC50) |
HDAC1 36.4 ± 0.2 nM (IC50) |
HDAC2 89.9 ± 0.7 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | EC50 |
>10000 nM
Compound: 3b
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Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
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[PMID: 27754681] |
| HL-60 | IC50 |
51.68 nM
Compound: 17
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Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
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[PMID: 34942071] |
| HL-60 | GI50 |
121 nM
Compound: 18
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Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against p53-null human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| K562 | EC50 |
2160 nM
Compound: 3b
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Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
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[PMID: 27754681] |
| Kasumi 1 | GI50 |
17.8 nM
Compound: 18
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Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against human Kasumi 1 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| MOLM-13 | IC50 |
102.7 nM
Compound: 17
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Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
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[PMID: 34942071] |
| MOLM-14 | EC50 |
76.64 nM
Compound: 3b
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Cytotoxicity against human MOLM-14 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human MOLM-14 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
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[PMID: 27754681] |
| MV4-11 | EC50 |
36.37 nM
Compound: 3b
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Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
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[PMID: 27754681] |
| MV4-11 | IC50 |
36.37 nM
Compound: 17
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Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
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[PMID: 34942071] |
| MV4-11 | GI50 |
16 nM
Compound: 18
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Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| NB-4 | GI50 |
19.5 nM
Compound: 18
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Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against p53-null human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
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[PMID: 38224650] |
| RPMI-8226 | EC50 |
>10000 nM
Compound: 3b
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Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
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[PMID: 27754681] |
| RS4-11 | EC50 |
151.7 nM
Compound: 3b
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Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
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[PMID: 27754681] |
| RS4-11 | IC50 |
81.97 nM
Compound: 17
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Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
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[PMID: 34942071] |
| U-937 | IC50 |
161.4 nM
Compound: 17
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Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 34942071] |
Chemical Information
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CAS. Nr. 2044701-99-5
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Appearance Solid
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Molecular Weight 337.42
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Formel C20H23N3O2
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Color White to off-white
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SMILES
O=C(/C=C/C1=CC=CC=C1)NCC2=CC=C(C=C2)C(NNCCC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Metab Eng
Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction. [Abstract]2023 Nov:80:94-106. PMID: 37717646
Lösungsmittel & Löslichkeit
DMSO : 5 mg/mL (14.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9637 mL | 14.8183 mL | 29.6367 mL | 74.0916 mL |
| 5 mM | 0.5927 mL | 2.9637 mL | 5.9273 mL | 14.8183 mL | |
| 10 mM | 0.2964 mL | 1.4818 mL | 2.9637 mL | 7.4092 mL |
HDAC3-IN-1 Related Classifications
HY-117374 Related Classifications
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