country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-150595

Copy Link Print Information

HDAC6-IN-10

HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC₅₀ of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2408286-73-5
Formel: C₂₁H₂₀N₄O₄
Molecular Weight:392.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

HDAC6-IN-10 Chemical Structure

CAS. Nr.: 2408286-73-5

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HDAC6

0.73 nM (IC₅₀)

HDAC10

105 nM (IC₅₀)

HDAC8

513 nM (IC₅₀)

HDAC7

752 nM (IC₅₀)

HDAC11

1800 nM (IC₅₀)

HDAC9

2560 nM (IC₅₀)

HDAC5

4370 nM (IC₅₀)

HDAC4

5620 nM (IC₅₀)

HDAC1

8020 nM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
RPMI-8226	IC₅₀	33.183 μM Compound: 21b	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay	[PMID: 31865013]
U-266	IC₅₀	43.233 μM Compound: 21b	Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay	[PMID: 31865013]

In Vitro

HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6^[1].
HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HCT-116
Concentration:

0.1, 1 and 10 μM
Incubation Time:

24 hours
Result:

Showed a dose-dependent increase in the level of Ac-tubulin.

Cell Proliferation Assay^[1]

Cell Line:

RPMI-8226 and U266 cells
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Showed antiproliferative activities against RPMI-8226 and U266 with the IC₅₀s of 33.183 μM and 43.233 μM, respectively.

Chemical Information

CAS. Nr. 2408286-73-5
Molecular Weight 392.41
Formel C₂₁H₂₀N₄O₄
SMILES

O=C(NO)C1=CC=C(CN2C([C@@H](CC3=CNC4=C3C=CC=C4)NC(C2)=O)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xin Chen, et al. Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. Eur J Med Chem. 2020 Feb 1;187:111950. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

HDAC6-IN-10

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HDAC6-IN-10 Related Classifications

HY-150595 Related Classifications