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Art. -Nr.: HY-187630

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KNI-174

KNI-174 is a potent and selective HIV-1 protease inhibitor and antiviral agent. KNI-174 targets and inhibits HIV-1-specific aspartic protease, thereby blocking retroviral proliferation. KNI-174 can be used in research related to acquired immunodeficiency syndrome (AIDS).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 141804-42-4
Formel: C₃₆H₄₅N₅O₇S
Molecular Weight:691.84

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KNI-174 Chemical Structure

CAS. Nr.: 141804-42-4

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

HIV-1

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
ATH-8 cell line	IC50	276 ng/mL	HIV-1 antiviral activity against ATH8 cells, quantified as inhibition of HIV-1 replication. HIV-1 antiviral activity against ATH8 cells, quantified as inhibition of HIV-1 replication.	8490108

In Vitro

KNI-174 potently inhibits HIV-1 replication in the ATH8 cell line with an IC₅₀ of 276 ng/mL (0.40 μM)^[1].
KNI-174 potently inhibits HIV-1 replication in PHA-PBM with an IC₅₀ of 138 ng/mL (0.20 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2 (Elimination)	CL_total	V₁	V_dss	MRT	AUC_0-last	AUC_0-∞	T_1/2 (Distribution)
Rat^[1]	10.0 mg/kg	i.v.	3.97 h	9.53 mL/min	544 mL/kg	7070 mL/kg	3.14 h	4.42 μg·h/mL	4.80 μg·h/mL	5.07 min

Chemical Information

CAS. Nr. 141804-42-4
Molecular Weight 691.84
Formel C₃₆H₄₅N₅O₇S
SMILES

CC(C)(C)NC([C@H]1N(CSC1(C)C)C([C@@H](O)[C@@H](NC([C@H](CC(N)=O)NC(COC2=CC=CC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kiriyama A, et al. Pharmacokinetic study of a tripeptide HIV-1 protease inhibitor, KNI-174, in rats after intravenous and intraduodenal administrations. Biopharmaceutics & drug disposition. 1993 Apr;14(3):199-207.

[2]. Kiriyama A, et al. Comparison of a new orally potent tripeptide HIV-1 protease inhibitor (anti-AIDS drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations. Biopharmaceutics & drug disposition. 1993 Nov;14(8):697-707.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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