KIR2DL3 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Gene

Also Known as p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3804

About KIR2DL3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,738,513-54,753,052 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 56 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

KIR2DL3 Products (1)

mRNA	Protein	Name
NM_015868.3	NP_056952.2	killer cell immunoglobulin-like receptor 2DL3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8574854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIR2DL3 Protein Structure

Ig_2

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
killer cell immunoglobulin-like receptor 2DL3	CD158 antigen-like family member B2

KIR2DL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIR2DL3	P43628	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	KIR2DL3	P43628	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	KIR2DL3	P43628	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	KIR2DL3	P43628	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	KIR2DL3	P43628	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	KIR2DL3	P43628	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	KIR2DL3	P43628	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	KIR2DL3	P43628	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	KIR2DL3	P43628	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	HLA-B	Homo sapiens	P01889	Affinity Chrom	19858347
Intra	KIR2DL3	P43628	HLA-C	Homo sapiens	P10321	Affinity Chrom	18322206
Intra	KIR2DL3	P43628	HLA-C	Homo sapiens	P10321	Affinity Chrom	19858347
Intra	KIR2DL3	P43628	ADGRE2	Homo sapiens	Q9UHX3	Validated Y2H	32296183
Intra	KIR2DL3	P43628	GPR108	Homo sapiens	Q9NPR9	Validated Y2H	32296183
Intra	KIR2DL3	P43628	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	KIR2DL3	P43628	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	KIR2DL3	P43628	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	SNORC	Homo sapiens	Q6UX34	Validated Y2H	32296183
Intra	KIR2DL3	P43628	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
Intra	KIR2DL3	P43628	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	KIR2DL3	P43628	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	KIR2DL3	P43628	ATP6V0E1	Homo sapiens	O15342	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	ATP6V0E1	Homo sapiens	O15342	Y2H Array	32296183
Intra	KIR2DL3	P43628	PLPPR2	Homo sapiens	Q96GM1	Validated Y2H	32296183
Intra	KIR2DL3	P43628	HLA-C	Homo sapiens	Q53YP1	Affinity Chrom	19858347
Intra	KIR2DL3	P43628	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	KIR2DL3	P43628	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	KIR2DL3	P43628	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	KIR2DL3	P43628	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	KIR2DL3	P43628	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	KIR2DL3	P43628	RNF152	Homo sapiens	Q8N8N0	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	RNF152	Homo sapiens	Q8N8N0	Validated Y2H	32296183
Intra	KIR2DL3	P43628	RNF152	Homo sapiens	Q8N8N0	Y2H Array	32296183
Intra	KIR2DL3	P43628	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	KIR2DL3	P43628	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	KIR2DL3	P43628	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	KIR2DL3	P43628	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	KIR2DL3	P43628	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	KIR2DL3	P43628	PTPN11	Homo sapiens	Q06124	Pull Down	8648092
Intra	KIR2DL3	P43628	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	KIR2DL3	P43628	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	KIR2DL3	P43628	EMD	Homo sapiens	P50402	Validated Y2H	32296183
Intra	KIR2DL3	P43628	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	KIR2DL3	P43628	FUNDC2	Homo sapiens	Q9BWH2	Validated Y2H	32296183
Intra	KIR2DL3	P43628	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	KIR2DL3	P43628	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	KIR2DL3	P43628	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	KIR2DL3	P43628	PTPN6	Homo sapiens	P29350	Pull Down	8691154
Intra	KIR2DL3	P43628	PTPN6	Homo sapiens	P29350	SPR	8648092
Intra	KIR2DL3	P43628	PTPN6	Homo sapiens	P29350	CoIP	8691154
Intra	KIR2DL3	P43628	PTPN6	Homo sapiens	P29350	Pull Down	8574854
Intra	KIR2DL3	P43628	IFITM3	Homo sapiens	Q01628	Validated Y2H	32296183
Intra	KIR2DL3	P43628	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	KIR2DL3	P43628	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KIR2DL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70354	KIR2DL3 Protein, Human (HEK293, His)	P43628-1 (H22-H245)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75901	KIR2DL3 Protein, Human (HEK293, Fc)	AAX23102.1 (H22-H245)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78166	KIR2DL3 Protein, Human (Biotinylated, HEK293, His-Avi)	P43628-1 (H22-H245)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78474	KIR2DL3 Protein, Human (HEK293, His-Avi)	P43628-1 (H22-H245)	≥ 95%, as determined by Bis-Tris PAGE.

KIR2DL3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81501	KIR2DL3 Antibody (YA1246)	IHC-P	Human
HY-P81501A	KIR2DL3 Antibody (YA1246)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Chronic Nk-Cell Lymphocytosis	Nk-Cell Large Granular Lymphocyte Lymphocytosis Chronic Lymphoproliferative Disorder Of Nk-Cells
Psoriasis
Nk Cell Deficiency
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Amelogenesis Imperfecta, Type Ie	Aih1 Amelogenesis Imperfecta Type 1e AI1E Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1 Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth Enamel Hypoplasia, X-Linked Amelogenesis Imperfecta Type Ie Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1 Enamel Hypoplasia X-Linked Amelogenesis Imperfecta, X-Linked 1 Amelogenesis Imperfecta, Type 1e Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth X-Linked Amelogenesis Imperfecta 1 X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1 X-Linked Enamel Hypoplasia Amelogenesis Imperfecta X-Linked 1 Amelogenesis Imperfecta 1e Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth Xai X-Linked Amelogenesis Imperfecta Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07301	KIR2DL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07303	KIR2DL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown