RIN3 - Ras and Rab interactor 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79890

About RIN3

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,513,781-92,688,994 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 13.0), spleen (RPKM 13.0) and 24 other tissues.

Summary

Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RIN3 Products (2)

mRNA Protein Name
NM_001319987.2 NP_001306916.1 ras and Rab interactor 3 isoform 2
NM_024832.5 NP_079108.3 ras and Rab interactor 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
21586568 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
21586568 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of negative regulation of mast cell chemotaxis IMP
IMP: Inferred from mutant phenotype
23185384 GOA
acts upstream of or within negative regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
23185384 GOA
acts upstream of or within regulation of vesicle size IDA
IDA: Inferred from direct assay
32552912 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18486601 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
21586568 GOA
located in early endosome IDA
IDA: Inferred from direct assay
21586568 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
18486601 GOA
located in vesicle IDA
IDA: Inferred from direct assay
32552912 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIN3 Protein Structure

VPS9

VPS9: Vacuolar sorting protein 9 (VPS9) domain (740 - 841)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 985 a.a.
Protein Preferred Names Protein Names

ras and Rab interactor 3

  • RAB5 interacting protein 3

RIN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RIN3 Q8TB24 CD2AP Homo sapiens Q9Y5K6
Anti Tag CoIP
32552912
Intra
RIN3 Q8TB24 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
RIN3 Q8TB24 BIN1 Homo sapiens O00499
Anti Tag CoIP
32552912
Intra
RIN3 Q8TB24 BIN1 Homo sapiens O00499
Anti Tag CoIP
12972505
Intra
RIN3 Q8TB24 BIN1 Homo sapiens O00499
Y2H
12972505
Intra
RIN3 Q8TB24 BIN1 Homo sapiens O00499
Pull Down
12972505
Intra
RIN3 Q8TB24 PLCG1 Homo sapiens P19174
Pull Down
17474147
Intra
RIN3 Q8TB24 PLCG1 Homo sapiens P19174
Peptide Array
17474147
Intra
RIN3 Q8TB24 CRK Homo sapiens P46108
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Paget'S Disease Of Bone

  • Osteitis Deformans

  • Paget Disease Of Bone

  • Osseous Paget'S Disease

  • Paget Disease Of Bone, Familial

  • Bone Paget Disease

  • Familial Paget'S Disease Of Bone

  • Paget'S Bone Disease

  • Familial Paget Disease Of Bone

  • Paget Disease, Bone

  • Pdb

  • Pagets Bone Disease
Myostatin-Related Muscle Hypertrophy

  • Mslhp

  • Muscle Hypertrophy Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-139990 CSF1R-IN-3 Inhibitor 98.10% Unkown
HY-157398 EGFR T790M/L858R-IN-3 Inhibitor / Unkown
HY-161567 OX2R-IN-3 Antagonist / Unkown
HY-RS11984 RIN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20811 Rin3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27325 Rin3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RIN3 VGNC VGNC:45588
Rattus norvegicus RIN3 RGD RGD:1305849
Macaca mulatta RIN3 VGNC VGNC:76771
Felis catus RIN3 VGNC VGNC:64635
Mus musculus RIN3 MGD MGI:2385708
Bos taurus RIN3 VGNC VGNC:53950
Others RIN3 NCBI