2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. CSF1R-IN-3

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity.

For research use only. We do not sell to patients.

CSF1R-IN-3 Chemical Structure

CSF1R-IN-3 Chemical Structure

CAS No. : 2760584-90-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 531 In-stock
Solution
10 mM * 1 mL in DMSO USD 531 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2150 In-stock
100 mg USD 3500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

CSF1R-IN-3 Related Antibodies

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Description

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].

Molecular Weight

574.67

Formula

C30H38N8O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1NC2=CC(NC(NC3=NOC(C(C)(C)C)=C3)=O)=CC=C2/C1=C/C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (108.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7401 mL 8.7006 mL 17.4013 mL
5 mM 0.3480 mL 1.7401 mL 3.4803 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7401 mL 8.7006 mL 17.4013 mL 43.5032 mL
5 mM 0.3480 mL 1.7401 mL 3.4803 mL 8.7006 mL
10 mM 0.1740 mL 0.8701 mL 1.7401 mL 4.3503 mL
15 mM 0.1160 mL 0.5800 mL 1.1601 mL 2.9002 mL
20 mM 0.0870 mL 0.4350 mL 0.8701 mL 2.1752 mL
25 mM 0.0696 mL 0.3480 mL 0.6961 mL 1.7401 mL
30 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4501 mL
40 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0876 mL
50 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8701 mL
60 mM 0.0290 mL 0.1450 mL 0.2900 mL 0.7251 mL
80 mM 0.0218 mL 0.1088 mL 0.2175 mL 0.5438 mL
100 mM 0.0174 mL 0.0870 mL 0.1740 mL 0.4350 mL
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CSF1R-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSF1R-IN-32760584-90-3c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Roralantiproliferativecolorectal cancer cellsmigrationmacrophagesM2-like macrophagesM1 phenotypeantitumor immunityInhibitorinhibitorinhibit

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