SZV-558
SZV-558 is a potent and selective MAO-B inhibitor with IC50 values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1648929-13-8
- Formule: C13H16ClN
- Masse moléculaire:221.73
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
rMAO-B 50 nM (IC50) |
hMAO-B 60 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
3500 nM
Compound: 1
|
Inhibition of human recombinant MAO-B expressed in Sf9 cells using 5-phenylacetaldehyde substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
Inhibition of human recombinant MAO-B expressed in Sf9 cells using 5-phenylacetaldehyde substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
|
[PMID: 25627172] |
| Sf9 | IC50 |
60 nM
Compound: 1
|
Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
|
[PMID: 25627172] |
Chemical Information
-
CAS No. 1648929-13-8
-
Masse moléculaire 221.73
-
Formule C13H16ClN
-
SMILES
C#CCN(CC(C1=CC=CC=C1)=C)C.Cl
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)