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Cat. No.: HY-103637B

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Vimirogant hydrobromide

(Synonyms: VTP-43742 hydrobromide)

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CAS No.: 2115761-82-3
Formule: C₂₇H₃₇Br₂F₃N₄O₃S
Masse moléculaire:714.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vimirogant hydrobromide Chemical Structure

CAS No.: 2115761-82-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

IC₅₀ & Target^[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC₅₀)

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Chemical Information

CAS No. 2115761-82-3
Masse moléculaire 714.48
Formule C₂₇H₃₇Br₂F₃N₄O₃S
SMILES

O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4.Br.Br
Synonyms

VTP-43742 hydrobromide
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gege C. RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345. Expert Opin Ther Pat. 2017;27(1):1-8. [Content Brief]

[2]. Gerard McGeehan, et al. VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945). J Immunol May 1, 2015, 194 (1 Supplement) 208.5-208.5.

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Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Vimirogant hydrobromide

Voir tous les produits spécifiques à Isoform ROR