pH Receptor Probe (solution)
Based on 1 Customer Validation
pH Receptor Probe (solution) is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. pH Receptor Probe has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. pH Receptor Probe has been used as a pH sensor of lysosomal compartments.
Solvent and concentration: DMSO: 10 mM
For research use only. We do not sell to patients.
- CAS No.: 312961-83-4
- Formula: C31H36N2O8S2
- Molecular Weight:628.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Solvent and concentration: DMSO: 10 mM
pH Receptor Probe technology utilizes the general ability of GPCRs to be internalized into the endosomal pathway of a cell in response to agonist ligands. The pH Receptor Probe dye is fluorescent in acidic environments, but nonfluorescent at neutral pH. When pH Receptor Probe is bound to a receptor on the extracellular surface of the cell, it is essentially nonfluorescent. On internalization into a cell, it displays a significant increase in fluorescence[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 312961-83-4
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Appearance Liquid
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Molecular Weight 628.76
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Formula C31H36N2O8S2
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Color Dark blue to black
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SMILES
O=C(CCCCCN1C2=CC=C(S(=O)(O)=O)C=C2C(C)(C)/C1=C\C=C\C=C\C3=NC4=C(C3(C)C)C=C(S(=O)(O)=O)C=C4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Patrick MJ, et al. Intracellular pH measurements using perfluorocarbon nanoemulsions. J Am Chem Soc. 2013 Dec 11;135(49):18445-57. [Content Brief]
[2]. Elaine J Adie, et al. CypHer 5: a generic approach for measuring the activation and trafficking of G protein-coupled receptors in live cells. Assay Drug Dev Technol. 2003 Apr;1(2):251-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
pH Receptor Probe (solution) Related Classifications
HY-DY1071 Related Classifications
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