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CDCP1 Protein, Rat (HEK293, His)

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CDCP1 is a cell surface glycoprotein that may contribute to autoimmune diseases such as encephalomyelitis, multiple sclerosis, and inflammatory arthritis. CDCP1 mediates anti-adhesion and anti-migration by negatively regulating integrin receptors. CDCP1 promotes tumor proliferation and metastasis by activating MAPK/ERK and AKT signaling pathways. CDCP1 Protein, Rat (HEK293, His) is the recombinant rat-derived CDCP1 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Rat
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

CDCP1 is a cell surface glycoprotein that may contribute to autoimmune diseases such as encephalomyelitis, multiple sclerosis, and inflammatory arthritis. CDCP1 mediates anti-adhesion and anti-migration by negatively regulating integrin receptors. CDCP1 promotes tumor proliferation and metastasis by activating MAPK/ERK and AKT signaling pathways. CDCP1 Protein, Rat (HEK293, His) is the recombinant rat-derived CDCP1 protein, expressed by HEK293 , with C-His labeled tag.

Background

CDCP1, a cell surface glycoprotein, is a ligand for CD6, a receptor molecule expressed on certain T cells that may play a role in T cell migration and chemotaxis. CDCP1 may lead to autoimmune diseases such as encephalomyelitis, multiple sclerosis and inflammatory arthritis. CDCP1 mediates anti-adhesion and anti-migration by negatively regulating integrin receptors. CDCP1 promotes tumor proliferation and metastasis by activating MAPK/ERK and AKT signaling pathways[1][2][3].

Technical Parameters

  • Species Rat
  • Source HEK293
  • Tag C-8*His
  • Accession

    D3ZVA1 (S29-T666)

  • Gene ID
    301082  [NCBI]
  • Molecular Construction
    • N-term
    • CDCP1 (S29-T666)
      Accession # D3ZVA1
    • 8*His
    • C-term
  • Protein Length

    Partial

  • Synonyms

    CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With Src Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen

  • AA Sequence

    SEIALPRGSDITVHIKLVSPALPVKFCYIVVSRQHVTELTIRPGERKSFTFSCNNPEKHYVLKIEKNIDCMSGPCPFGEVRLQPSKSELPILNRTYIWDVRAHKSIGLELQFATPRLRQIGPGESCADGVTHSISGHIDATEVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNISGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPGGFPEDELMTWQFVVPAHLRASVSFLNFNVSNCERKEERVEYYIPGSTTNPEVFRLEDQQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQRPQNESNITYMVDLSQERTMSLTIEPRPVKHGRRFVPGCFVCLDSRTCSTNVTLTAGSKHKISFLCDDLARLWMNVEKTLSCLDHRYYYGKSFNLQVPKDILQLPVQLHDFSWKLLVPKDRLGLMLVPGQKLQQHTRERPCNTSFGYQVASTTPGQDLYFGSFCPGGSIEKIQVKQNSSVTLRTYAPGFQQEVSKQVLTVSLIPYFKEEGIFTVTPDSKNKVYLRSPNWDRGLPALSSVSWNISVPSNQVACLTFFRERSGLACQSGRAFMIIQEQQTRAEEIFSLEEEVLPKPSFHHHSFWVNISNCSPMNGKQLDLLFWVTLTPRTVDLT

  • Predicted Molecular Mass

    73.1 kDa

  • Molecular Weight

    Approximately 90-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Purity

    ≥ 95%, as determined by Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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